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Abundance represents the metabolite level difference between conditioned and virgin media (n = 3 technical replicates from one experiment)

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Gentle Exfoliation: The spicules facilitate mild exfoliation by removing dead skin cells, refining skin texture without causing irritation

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As shown in Figures S3A,B in Supplementary Material, NBDHEX inhibited GSTP enzymatic activity but exhibited no cytotoxity at 0.5 M concentration