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Ethical approval and consent to participate The present study involved a retrospective analysis of data from Thai population cohorts that were conducted following the principles outlined in the Declaration of Helsinki

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The mechanism of direct toxicity is thought to involve mitochondrial dysfunction, oxidative stress, and disruption of intracellular calcium homeostasis

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The peptide's exceptional selectivity for senescent cells, combined with its well-characterized mechanism of FOXO4-p53 interaction disruption, provides researchers with powerful capabilities for investigating senescence biology that were previously impossible to study