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A comparative study of germ-free and microbially colonized mice indicated that the gut microbiota can induce specific iron-related protein signaling pathways and alter the perception of iron by intestinal epithelial cells [67]

Bibcode:2011AcPPl..33.1981G

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Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements

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