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Who might benefit from AOD 9604

Nuclear factor-B signaling in the pathogenesis of diabetic neuropathy

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

In the case of an existing vitamin B12 deficiency, the blood-forming tissues are affected first - this can therefore lead to pernicious anaemia

Individuals with risk factors for B12 deficiency including strict vegans, those with gastrointestinal conditions, patients taking long-term metformin or proton pump inhibitors, and older adultsshould discuss screening with their GP, even in the absence of obvious symptoms