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& Kass, R

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Extant studies have found that AS-IV has protective effects on the kidneys and improves renal fibrosis by enhancing the expression of phosphorylated (p-) Smad3 C/p21 and nuclear factor (erythroid-derived 2)-like 2(Nrf2)/Heme oxygenase-1(HO-1), thereby inhibiting p-Smad 3L/plasminogen activator inhibitor (PAI)-1 and reducing ROS and -SMA levels (Qin et al., 2023)

In rats, at least, a ketogenic diet can increase glutathione levels

23,24 Renal dysfunction is both a cause and consequence of HU, creating a vicious cycle that exacerbates the conditions severity