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doi:10.1016/j.juro.2008.01.094

A high activity was encountered, Ki = 5.1 nM, to be compared with 23 (HA08) with a Ki of 3.3 nM, the latter comprising a 13-membered macrocyclic system

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Das Problem ist ein anderes: Die meisten dieser Empfehlungen stammen aus den USA, wo die regulatorischen Rahmenbedingungen grundlegend anders sind als in Deutschland