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Microscopically, controls presented a diffuse edema of interlobar septe, interlobular septe, interacinal spaces, focal expansion of intercellular spaces, a diffuse occurrence of 510 necrotic acinar cells and a focal occurrence of 1116 necrotic cells/HPF, up to four foci of hemorrhage, up to six foci of fat necrosis, and perivascular infiltration of 610 leukocytes/HPF in the 4.30 h5 h assessment period (Figure 6)

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614,636 NRF2, a key regulator of antioxidant response, is likely activated by Kelch-like ECH-associated protein 1 (KEAP1) in response to NAPQI