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This matters because many adults with low B12, whether from dietary restriction, aging, or conditions like pernicious anemia, cannot absorb enough B12 through food or oral supplements alone

The FDA has also flagged safety concerns regarding certain bulk substances used in compounding, as well as broader compounding risks

Insider's takeaway Vitamin B12 injections are for those with a severe B12 deficiency or conditions that prevent their body from effectively absorbing the vitamin, Moreno says

Injection site reactions , including redness, itching, or swelling, occur in approximately 23% of patients

It facilitates healthy blood cell creation, nerve cell support, and protein metabolism