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doi: 10.1093/toxsci/kfn251 110 KafleA.TimilsinaA.GautamA.AdhikariK.BhattaraiA.AryalN

P21 (Cerebrolysinderived) - Best for: Advanced memory, neuroplasticity - Mechanism: Enhances learning & longterm memory formation How They Work (Key Mechanisms) - BDNF/NGF upregulation: Grow & repair neurons - Neurotransmitter modulation: Dopamine, serotonin, acetylcholine, glutamate - Bloodbrain barrier penetration: Direct brain action - Antioxidant & antiinflammatory: Protect neurons - Synaptic plasticity: Strengthen neural connections Common Applications - Cognitive decline: Aging, mild cognitive impairment - Neurological recovery: Stroke, TBI, neurodegeneration - Performance: Study, work, focus under pressure - Mood & stress: Anxiety, emotional regulation - Research: Preclinical models for brain health Important Notes - Most are not FDAapproved for cognitive enhancement (Semax/Selank/Cerebrolysin approved elsewhere) - Dosing & administration vary (nasal, oral, injection) - Use under medical supervision

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As the rate of absorption is 0.46 h 1 , which is less compared to that of diosgenin and hydroxychalcone, it has higher T max value of 6 h