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The paper explores the science at the intersection of metabolic hormones and precision nutrition and multi-target therapies, like tirzepatide and retatrutide.

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Phase 1 corresponds to a high level of activity in the primary afferent as a result of C-fiber activation due to peripheral stimulation, whereas phase 2 results from a continuous low-level small afferent input, together with a facilitated state of spinal processing [21]

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The article highlights the potential of this peptide duo in promoting tissue repair and reducing inflammation, making it a promising area for further research in medical treatments