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Adequate GSH maintains GPX4 in its reduced state, preventing oxidative inactivation, whereas GSH depletion leads to decreased GPX4 activity or even complete inactivation

Journal of the American Ceramic Society 47, 649650 (1964)

Kidney epithelial cell line HEK293 subclone HEK293A (human embryonic kidney cells transformed with sheared human adenovirus type 5 DNA) were obtained from Invitrogen

This maintenance phase begins only after the initial deficiency has been corrected and the patients blood markers have stabilized within the normal range

Increased granulosa cell apoptosis is a primary reason for diminished ovarian function, resulting in accelerated follicular atresia and increased oocyte apoptosis [36, 37]