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PMID: 12177109 Smyth JF, Bowman A, Perren T, Wilkinson P, Prescott RJ, Quinn KJ, Tedeschi M

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Mitochondrial cascade hypothesis: Mitochondrial dysfunction and the accumulation of reactive oxygen species lead to neuronal damage and ultimately contribute to the pathogenesis of neurodegenerative diseases, particularly AD

Moreover, CRC patients with PIK3CA mutations may experience more benefits from this treatment method compared to those with PIK3CA wild-type CRC (89)