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337 Concurrently, age-related decreases in PINK1/Parkin-mediated mitophagy promote oxidative stress and mitochondrial dysfunction, which can trigger synovial inflammation and reduce the osteoclast activity critical for healthy bone remodeling, thereby contributing to joint damage and motor impairment

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Intracellular antioxidant system of melanocytes Due to the high risk of melanocytes exposure to harmful and prooxidant factors of the external environment, these cells are characterized by naturally well-developed complex antioxidant systems, including enzymatic and non-enzymatic antioxidants (Fig