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Once the therapeutic effect begun, the therapeutic effect is continuous, and neither of the continuous ligation-induced disturbances reappeared (Vukojevic et al., 2018

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When PD-1 binds to PD-L1 or PD-L2, the intracellular domain of PD-1 becomes phosphorylated, leading to the recruitment of SHP-2 phosphatase enzymes

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