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Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)

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They should be sourced from licensed compounding pharmacies, not unregulated online vendors, and used with appropriate lab monitoring

Different mechanisms, addressing different prerequisites of the same outcome