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It is thought that over time, the disease shifts from an early hypermetabolic state to a hypometabolic state with decreased metabolites (251) and reduced energy production (59), correlating with patient clinical profiles (185)

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Elevated expression of zip6 results in nuclear retention of Snail, which is also known to be a zinc-finger transcription factor, which subsequently represses the expression of E-cadherin, resulting in cell migration 322 (Fig

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