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However, the same clinical trial revealed that only 6.2% of patients maintained any benefit at 6 months post-treatment compared to 0% in the placebo group

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74 Notably, the upregulation of ZEB1 inhibited expression of the gemcitabine transporter via ITGA3/ITGB1/31 signaling and c- JNK pathway, which leads to chemoresistance both in vitro and in vivo