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Aging 3 , 297312 (2023)

The pharmaceutical formulation disclosed herein may comprise 10-25% w/v, such as more than 10% w/v and less than 22% w/v, such as about 10-20% w/v, such as about 12- 18% w/v, such as about 10-17.5% w/v, such as about 11.25-15%, such as about 15% w/v hydroxypropyl-beta-cyclodextrin having a minimum of about 0.4 hydroxypropyls per glucose unit and a maximum of about 1.0 hydroxypropyls per glucose unit

This activates protein kinase A, which then activates hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids that can be burned for energy

Since creatine synthesis is responsible for most of the methyl group transfers that result in Hcy formation, creatine supplementation might inhibit Hcy production and reduce free radical formation

The timeline for expected therapeutic response may vary based on the condition being treated and individual patient factors