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Morelli et al

The results showed that the chemiluminescence intensity at the tumor site gradually weakened or even disappeared with the progression of NP4 treatment, while the chemiluminescence intensity in mice without drug treatment and those treated with Ru(II)-OH and NP2 gradually increased

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Hum Reprod (2011) 26(10):2799806

The local-versus-systemic distinction is one more reason the strong transgenic findings cannot be assumed to predict what a circulating IGF-1 LR3 dose would do, and it further separates the natural, loading-responsive biology (closer to the MGF concept) from the pharmacology of an engineered systemic agonist