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The authors found that pre-treatment with nicotine greatly alters the response to cocaine in terms of addiction-related behavior and synaptic plasticity (changes in synaptic strength) in the striatum, a brain region critical for addiction-related rewards

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Following a systematic approach ensures consistency, prevents errors, and helps in creating customized or standardized packaging for any cigarette type

Rounding out the cast are the young Calista Flockhart and Sam Rockwell

Because all tobacco smokers were aged older than 50 years, researchers also conducted additional age- and sex-matched subgroup analyses that included 30 marijuana smokers (23 men), 33 tobacco-only smokers (18 men) and 29 nonsmokers (17 men)