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Its accelerated approval was primarily based on a compelling reduction in plasma neurofilament light chain (NfL), a biomarker of neuronal damage, which decreased by approximately 60% in the tofersen group compared to 20% in the placebo group (44)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimers Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

10.3390/antiox6040079 Antioxidants 39 MiyazakiT.HondaA.IkegamiT.MatsuzakiY

A safety-first approach matters because: Supplements arent regulated the same way as prescription medications, and dosages/quality can vary