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Moreover, HK2 also plays a direct or indirect role in the transcriptional activation and phosphorylation of certain signaling molecules in muscle and bone tissues ( Inflammation is the driving factor of OA, and NOD-like receptor protein 3 (NLRP3) expression level is significantly increased in the synovium of articular cartilage of OA patients

In addition, estrogen is also known to activate insulin/IGF-1 (Lee et al., 2004) and PI3K/Akt (Mangan et al., 2014) pathways, potentially enhancing the mechanisms regulating MPS (Hansen et al., 2014)

Genitourinary System Ureteral spasm, spasm of vesical sphincters, and urinary retention

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Time to initial irAE was similar between the two groups (2.8 versus 2.7 months