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Effect of adjunctive Lmethylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial

Endothelial dysfunction, arginase activation, decreased NO bioavailability, and increased vascular stiffness are also important factors in leading hypertension (Ryoo et al., 2011

Disrupted iron homeostasis in the brain has been increasingly implicated in the pathology of many CNS diseases, where excessive iron accumulation can lead to oxidative stress, neuroinflammation, and ferroptotic cell death in vulnerable brain regions (Salvador et al., 2010)

This culminates in a combined insult of oxidative stress, excessive autophagy, and inflammatory damage in the liver

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