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In light of its superior safety profile, Health Canada mandated a label change in 2013 advising thorough consideration of NRT before prescribing either varenicline or bupropion to any smoker, further stating that in many cases, nicotine replacement therapy should be tried before prescribing varenicline or bupropion [9], emphasizing the need to optimize the effectiveness of this first-line medication

Bowl (smoking) A bowl , when referred to in pipe smoking, is the part of a smoking pipe or bong that is used to hold tobacco, cannabis, or other substances