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The AngIV Analog D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 has a Much Longer Circulating Half-Life than Norleual (Nle-Tyr-Leu--(CH 2 NH 2 ) 3-4 -His-Pro-Phe (SEQ ID NO: 1)): As anticipated from the in-vitro blood stability data, D-Nle-Tyr-Ile-NH(CH 2 ) 5 CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats

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He first used a cream, then later switched to injections