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The p53 levels are regulated by negative feedback mediated by the E3 ubiquitin ligase MDM2 and its homolog MDMX (158)
Improves Tone of the Colon and Motility: It is believed a compound in coffee called theophylline dilates blood vessels in the large intestine, thus boosting blood flow and improving muscle tone and motility
Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]
Ahrn B, Leguizamo Dimas A, Miossec P, et al