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10.1101/gad.13.19.2514 Genes Dev

When we don't get enough iron, we may experience: Reduced capacity to exercise and skeletal muscle atrophy, even before iron deficiency anemia (IDA) develops Over time, IDA, resulting in abnormal red blood cell formation and symptoms such as fatigue, weakness, difficulty concentrating, impaired cognitive and immune function, and poor body temperature regulation IDA has also been linked to impaired glucose metabolism---potentially due to poor conversion of proinsulin to active insulin in the body

The established mechanisms provide substantial insights into the pathogenesis of diseases related to iron overload, while the recent mechanisms introduce innovative avenues for exploring potential therapeutic targets

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It remains an investigational medicinal product