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The discrepancy between demonstrated subcutaneous efficacy (or lack thereof) and marketed oral supplements creates a fundamental problem: commercially available AOD-9604 supplements likely deliver negligible systemic peptide due to oral bioavailability limitations

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82,88 Given that -cells only have extremely low LDHA activity to regenerate NAD + for glycolysis, NADH generated by glycolysis must be transferred into the mitochondria to be oxidized by complex I

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