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For example, a 2015 study published in The New England Journal of Medicine found that smokers who were assigned to use cigarettes with low nicotine content (between 0.4 and 2.4 milligrams of nicotine per gram of tobacco) smoked fewer cigarettes per day, and were less dependent on nicotine, than those who used regular cigarettes (with 15.8 milligrams of nicotine per gram of tobacco)