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In fact, the profound ROS accumulation characteristic of sickle RBCs has been demonstrated to be mainly caused by NADPH oxidase, which is regulated by Rac GTPase [179]

Sikiric P, Seiwetht S, Ruckman R, Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implication

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172 In a rat model, alpha-lipoic acid and glutathione reduced some of the adverse changes in blood parameters, including drops in red blood cell number and size as well as reductions in hemoglobin concentration brought about by intoxication with lead, cadmium, or copper

But the laboratory data is clear, and it aligns with the clinical observations of patients who report improvement when adding GLP-1 medications to their existing treatment regimens