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Because the body cannot make B12 on its own, it has to come from food (meat, fish, eggs, dairy) or from supplements

doi: 10.1177/0885328209356328

You only need to worry about air bubbles that extend from one side of the syringe to the other- any other bubble smaller than that is nothing to worry about

The mechanistic story emphasizes neurotransmitter system normalization rather than direct receptor agonism