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Despite being considered as distinct pathological events, oxidative stress, neuroinflammation and mitochondrial dysfunction interplay with and enhance each other (Picca et al., 2020) (Figure 2)

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Accordingly, 2D-electrophoresis and Western blot analyses revealed that pre-treatment with the NO donor SNAP further increased the Al 3+ -induced protein levels and activities of APX, SOD, and GR, whereas NOS inhibitor and cPTIO suppressed both the Al 3+ and the SNAP effect (Yang et al., 2013)

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