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Further doseresponse and steady-state administration studies will be required to optimize the dosing schedule for future trials to evaluate therapeutic efficacy

Hippocampal neurons transfected with mRFP- -actin alone or with shMet to knock down the c-Met receptor were stimulated with HGF (10 ng/ml), Dihexa (10-12 M) or Nle1-AngIV (10-12 M) for 48 hours

& Leeson, H

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The development of anti-cagrilintide antibodies has been observed in 46-73% of patients by week 26, with higher rates associated with longer treatment duration and higher doses