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In healthy tissue, the peptide maintains NO homeostasis by modestly increasing endothelial NOS (eNOS) for beneficial vasodilation while suppressing inducible NOS (iNOS) that drives pathological inflammation

The pathophysiology of astroglia is complex, highly heterogeneous and mutable: multiple pathology-associated phenotypes may co-exist and emerge and disappear during the progression of a neuropathology

The physical agitation can break the delicate amino acid bonds, damaging the molecule and rendering it ineffective

doi: 10.1093/jnci/85.18.1492 160 QiaoYLDawseySMKamangarFFanJHAbnetCCSunXDet al

This intricate pathophysiology leads to elevated blood glucose levels, a hallmark of this debilitating condition