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These studies indicate the potential of utilizing the de novo pathway, a less extensively studied pathway, as a therapeutic strategy for metabolic diseases Barth syndrome is a rare disease caused by mutations in the tafazzin gene encoding for cardiolipin (CL), a phospholipid specific for the mitochondria 303

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2 Glucocorticoid-induced osteoporosis (GIO) 2.1 Pathogenesis Both the cumulative dose and duration of exposure to GCs are risk factors for bone fractures [9, 13]

doi: 10.1016/j.phrs.2024.107100 34