In this study, we have developed a novel DDX3X degrader, J10, using the PROTAC strategy
Borthakur G, Tallman MS, Ofran Y, Foran J, Uy G, DiPersio J, Nagler A, Rowe J, Showel MM, Altman JK, Peled A, Abraham M, Pereg Y, Vainstein A, Oberkovitz G, Lustig TM, Brawer S, Bohana-Kashtan O, Cortes JE, Andreeff M
PMID: 18440504 Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB
Each serving provides 1000mg of this amino acid
What a COA (Certificate of Analysis) Should Include Identity Confirmation Mass spectrometry confirming correct molecular weight (~401 Da for GHK-Cu, ~340 Da for GHK alone) Explicit identification of the product as GHK-Cu (copper complex), not GHK alone Amino acid sequence verification matching Gly-His-Lys Purity Testing HPLC purity look for 98%+ purity HPLC chromatogram should show a single dominant peak Copper content analysis (atomic absorption or ICP-MS) confirming stoichiometric chelation Contamination Testing Endotoxin levels (bacterial contamination) Residual solvent analysis (acetonitrile, TFA) Heavy metals screening (other than the intentional copper) How to Verify a COA Is Legitimate Check the testing lab Reputable labs include Janoshik Analytical, MZ Biolabs, and Colmaric Analyticals