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These properties make it particularly relevant in contexts where oxidative stress drives tissue damage: photoaging, COPD, post-injury inflammation, and metabolic disease

Sparse clinical evidence versus real-world experience In a review of the evidence posted ahead of the meeting, they repeatedly note the data comes primarily from preclinical work involving animals and is quite limited for humans

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Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]