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The Journal of Clinical Endocrinology & Metabolism, 82 (5), 14721479

Inhibition of MEK1/2 increases AKT phosphorylation To test whether MEK inhibition can increase AKT phosphorylation to activate AKT, we knocked down MEK1 and MEK2 expressions with mek1 and mek2 siRNA, respectively

The complete comparison table Here are the three compounds in monotherapy, plus the CagriSema combination, placed within their respective reference trials