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342 Immune senescence, particularly of cytotoxic CD4 + T cells, 343 promotes chronic inflammation and the accumulation of somatic single-nucleotide variants in the CNS

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Squalene acts as a DNA-damage checkpoint inhibitor through intracellular induction of Wip1 expression (Tatewaki et al., 2016)

The bioavailability of 25(OH)VD in response to ingesting vitamin D supplementation significantly varies among individuals and is influenced by the status of the vitamin D-metabolizing genes [16,21,22,23]