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Moreover, the level of residual labelling of individual peptides positively correlated with their protein half-lives (measured independently in primary human fibroblasts 36 ) (Extended Data Fig

Its effects on hemostasis appear context-dependent, varying with the type of vascular injury, the dose, and the route of administration

Glutamate transporters maintain the concentration of glutamate within the synaptic cleft at low levels, preventing glutamate-induced cell death (Kanai et al., 1994)

65 Thus, gain of detrimental effects is likely to be context-dependent and unique to specific situations and effective treatment will require understanding the distinctive situations under which they arise

doi: 10.1111/j.1365-2036.2011.04862.x