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The basic principle causing the radiation-induced toxicity is the excessive generation of reactive oxygen species (ROS) due to the radiolysis of cellular water, which in turn oxidizes the critical biomolecules such as lipid, protein, and DNA [36,37,38,39]

Accumulation of cytosolic dsdna contributes to fibroblast-like synoviocytes-mediated rheumatoid arthritis synovial inflammation

Otolaryngol Head Neck Surg 2002

The positive ratio of -6/-3 PUFA, vitamins (E, B, C, and -carotene), fibers, minerals (selenium, iron, zinc, iodine) are key components of the MeD and account for its beneficial effects [15, 62, 121, 186]

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