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An experimental study based on an IS mouse model and an OGD/R cell model has reported that neutral polysaccharides derived from Gastrodia elata can inhibit ferroptosis-mediated neuroinflammatory responses by activating the NRF2/HO-1 signaling pathway, significantly reducing the apoptosis rate of HT22 cells in the OGD/R model, and alleviating neuronal damage related to brain edema (Zhang et al., 2024)