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Alpha-lipoic acid has been most extensively studied for diabetic peripheral neuropathy, where it has been approved as a prescription treatment in Germany since the 1960s [2]

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Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis

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For example, cancer cells must adapt to steep nutrient gradients that characterize the natural tumor microenvironment (TME) (5-7)

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Yet, most remain at proof-of-concept or early preclinical stages, with limited scalability, regulatory clarity, and long-term safety validation

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D., Khavinson, V

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