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Although variability in compositional features exists in separate clinical cohort studies, AD patients demonstrate a differential abundance of several genera, mainly fewer Lachnospiraceae , Clostridiaceae and Ruminococcaceae , and Eubacterium , with more Bacteroides , Bifidobacterium, Enterobacteriaceae , Alistipes , and Akkermansia taxa (Vogt et al., 2017

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PP2A can be deactivated by ROS which may in turn inhibit Akt/PKB