The principles of dilution, concentration, and careful handling are universal
Previous studies revealed that the polysaccharides of BP (Chinese wolfberry) have immunomodulatory activity in vitro against RAW 264.7 cells via downregulating the level of tumor necrosis factor-alpha (TNF-), interlukin-1 (IL-1), interlukin-6 (IL-6), and nitric oxide (NO) secretion (162)
Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)
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Primary outcome was a favorable outcome (mRS 03) at 90 days