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Briefly, biopsies were flushed with 10 ml of ice cold PBS and minced into the small pieces

Estrogen enhances linkage in the vascular endothelial calmodulin network via a feedforward mechanism at the G protein-coupled estrogen receptor 1

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This may be due to the vicious cycle of increased lipid peroxidation and free radicals in cancer cells, while the decrease in GPx activity makes cancer tissues more susceptible to the damaging effects of free radicals