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Our cellular assays showed that the IGF1R activity in cells with the co-expression of WT and F701A was ~75% of that in cells expressing only the WT receptor, indicating that the WT:F701A heterodimer was indeed active (Fig

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Further experimental investigations are needed to determine whether the beneficial effects of any small molecules that stimulate or inhibit erythrocyte apoptosis are effective in the ex vivo or in vivo treatment of anemia, malaria, or systemic pathologies associated with eryptosis [211]