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Tumor angiogenesis is associated with intrinsic mechanisms such as the MAPK/PI3K and WNT/-catenin pathways, which contribute to drug resistance development 54

In addition, to evaluate changes in the testicular microenvironment after FOXO4-DRI treatment, we assessed levels of several common SASP factors in testis tissue, including IL-1, IL-1, IL-6, IL-10, TNF- and TGF-

These are three of the major hallmarks and causes of aging

However, the subjects in this study were described as having a rapidly aging cardiovascular system, a description that does not correspond to a particular clinical diagnosis [9]

Such data would be important for predicting the state of neuroendocrine aging and theoretically as interventions become available, be valuable in knowing when to begin therapy