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Unlike full-length human growth hormone, which binds the GH receptor and elevates IGF-1, AOD-9604 acts through a diacylglycerol second-messenger pathway in fat cells

Rhonda Patrick, a biomedical scientist and founder of FoundMyFitness, emphasizes: "NAD+ levels can go up when we exercise or fast, but NAD+ precursors like NR and NMN boost them further, supporting energy production and cellular repair."[17] She notes that combining lifestyle with supplementation yields optimal results

This leads to the frustrating situation of difficulty losing weight despite regular exercise and a good diet

Metabolic Regulation & Obesity Research

This makes it safe for patients who need fat reduction support without the metabolic complications associated with growth hormone therapy