Kim HD, Wei J, Call T, Ma X, Quintus NT, Summers AJ, et al
Obviously, this ferroptosis mechanism induced by Erastin is clearly distinct from the iron overloaddriven ferroptosis observed in EMS tissues, both are based on ROS-induced lipid peroxidation and its damage to the cell membrane, leading to cell death, but the driving mechanisms differ
& Kangawa, K
That study did not report efficacy outcomes, and estimated exposure over 24 h (AUC 0-24 h ), whereas our analysis estimated exposure over the effectiveness window (AUC 0-90 min ) which may be more relevant for PK/PD comparisons
These materials can serve as sustained-release stents for local body intervention, enhance drug lipophilicity, or act as scaffolds for various cytokines, stem cells, and drugs